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Atara Biotherapeutics, Inc. Engineer/Sr. Engineer, Process Development in Denver, Colorado

This position will work with the Technical Operations teams to develop and characterize cell therapy manufacturing processes and products.

The Engineer/Sr. Engineer will be responsible for designing and performing laboratory activities to support process development and process characterization of Atara’s cytotoxic T cell products. He/she will be responsible for cell processing, process engineering scale-up/scale-down, bioreactor process parameters, assessment of novel technologies, cryopreservation, and equipment maintenance. Under minimal supervision, you will be expected to design and perform experiments, organize and carefully document results, analyze and interoperate results, and communicate findings. The position will be based out of the newly established PD lab and provides an opportunity to get in on the ground floor of the establishment of Atara’s PD team.

Reports to: Director, Process Development

Location: Aurora, CO

Primary Responsibilities

  • Contribute substantially to the development of manufacturing processes for T-cell therapy products, including allo CAR-T products, using suspension bioreactor technologies.

  • Optimize stir tank bioreactor parameters and evaluate alternative technologies.

  • Design and execute process development studies to develop a thorough understanding of operating and performance parameters (Design space)

  • Scale-up stir tank bioreactor process for T-cell therapy products.

  • Develop perfusion bioreactor process for culturing for T-cell therapy products, including allo CAR-T products

  • Use engineering approaches to develop solutions to manufacturing process deficiencies.

  • Sets up, monitor, sample and analyze cell culture processes in bioreactors.

  • Performs multiplexed cell-based assays (killing assays, mixed lymphocyte reactions, proliferation assays, etc.) for process assessment and product characterization.

  • Document laboratory procedures and experiments with great attention to detail in laboratory notebooks

  • Assist in the development of standard operating procedures, analytical test methods, and analytical sampling plans.

  • Bachelor’s degree with 5+ years of experience for Engineer role OR Bachelor’s degree with 7+ years of experience for Sr. Engineer role

  • Experience with operating and optimizing bioreactor cultures and perfusion systems, preferably in a cell therapy application.

  • Knowledge and experience in mammalian cell culture / biotechnology related development (aseptic operations, cell biology, biochemistry, bioreactor operations)

  • Basic analytical skills including the following techniques: multicolor flow cytometry, cell-based bioassays, ELISA, etc.

  • Ability to follow laboratory procedures with attention to detail, and successfully execute experiments at the bench.

  • Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities.

  • Demonstrated ability to maintain lab execution records and perform data analysis.

We launched Atara Biotherapeutics in August 2012 to help patients with serious diseases and few therapeutic options. We’re named after Atara Ciechanover who suffered from cancer before passing away. We are considered a leading off-the-shelf T-cell immunotherapy company (Nasdaq ATRA) developing novel treatments for patients with cancer, autoimmune and viral diseases.

We’re proud of our team of 350+ Atarians co-located by design in South San Francisco (corporate headquarters) and Southern California (R&D and manufacturing headquarters in the northwest Los Angeles area) with a newly-established European headquarters in Zug, Switzerland. Atara also has a R&D site in the Denver, Colorado area and an office in New York City. Our Southern California hub is anchored by a new 90,000 sq. ft., state-of-the-art Atara T-Cell Operations and Manufacturing (ATOM) facility in Thousand Oaks, California.

Our mission – “Transform the lives of patients with serious medical conditions through pioneering science, teamwork, and a commitment to excellence.”

Our vision - “T-Cell Immunotherapy for every patient, any time.”

Atara offers a competitive benefits packages that includes medical/dental/vision benefits, life and disability, retirement and stock program, as well as a generous paid time off and wellness plan that supports the well-being of our staff. Visit to learn more

Visit to learn more.

Atara Bio is an equal opportunity employer and makes employment decisions on the basis of merit and other lawful factors. In accordance with applicable law, the Company prohibits discrimination based on race, color, religion, creed, sex, gender (including pregnancy, childbirth or medical condition related to pregnancy or childbirth), gender identity, expression or dysphoria, marital status, age, national origin or ancestry, physical or mental disability, medical condition, genetic information, veteran status, caregiver status, sexual orientation, transgender status or any other classification protected by federal, state or local laws or because of the individual’s association with a member of a protected group or connection to an organization or group related to a protected group.

We comply with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Atara Bio in the United States.

Official Title: Engineer/Sr. Engineer, Process Development

Job ID: 2021-1618

External Company Name: Atara Biotherapeutics, Inc.

External Company URL: